diff --git a/client/src/components/InlinePanel/index.js b/client/src/components/InlinePanel/index.js
index c450929286..e87b0cf35d 100644
--- a/client/src/components/InlinePanel/index.js
+++ b/client/src/components/InlinePanel/index.js
@@ -181,6 +181,23 @@ export class InlinePanel extends ExpandingFormset {
     return forms.length;
   }
 
+  getActiveFormsIndex() {
+    const choiceIds = [];
+    const forms = $('> [data-inline-panel-child]', this.formsElt).not(
+      '.deleted',
+    );
+    // eslint-disable-next-line func-names
+    forms.each(function () {
+      const id = $(this).attr('id');
+      const index = id.match(/\d+$/)[0];
+
+      if (index !== undefined && typeof parseInt(index, 10) === 'number') {
+        choiceIds.push(index);
+      }
+    });
+    return choiceIds;
+  }
+
   updateAddButtonState() {
     if (this.opts.maxForms) {
       const addButton = $('#' + this.opts.formsetPrefix + '-ADD');
diff --git a/client/src/components/MultipleChooserPanel/index.js b/client/src/components/MultipleChooserPanel/index.js
index 74ca3028fe..39bb799c3c 100644
--- a/client/src/components/MultipleChooserPanel/index.js
+++ b/client/src/components/MultipleChooserPanel/index.js
@@ -11,6 +11,27 @@ export class MultipleChooserPanel extends InlinePanel {
       ),
     );
 
+    const getChoiceSelectIds = () => {
+      const chooserIds = [];
+      const formsIndexes = this.getActiveFormsIndex();
+
+      for (const formIndex of formsIndexes) {
+        const formPrefix = `${opts.formsetPrefix}-${formIndex}`;
+        const chooserFieldId = `${formPrefix}-${opts.chooserFieldName}`;
+        const chooserWidget = this.chooserWidgetFactory.getById(chooserFieldId);
+
+        if (
+          chooserWidget !== null &&
+          chooserWidget.state !== null &&
+          chooserWidget.state.id !== null &&
+          typeof parseInt(chooserWidget.state.id, 10) === 'number'
+        ) {
+          chooserIds.push(chooserWidget.state.id);
+        }
+      }
+      return chooserIds;
+    };
+
     const openModalButton = document.getElementById(
       `${opts.formsetPrefix}-OPEN_MODAL`,
     );
@@ -30,6 +51,12 @@ export class MultipleChooserPanel extends InlinePanel {
         },
         { multiple: true },
       );
+      if (opts.allowDuplicates === 'True') {
+        openModalButton.setAttribute(
+          'chooserids',
+          getChoiceSelectIds().join(','),
+        );
+      }
     });
   }
 
diff --git a/client/src/includes/chooserModal.js b/client/src/includes/chooserModal.js
index e05a339d0d..9a7a3fae2f 100644
--- a/client/src/includes/chooserModal.js
+++ b/client/src/includes/chooserModal.js
@@ -234,6 +234,8 @@ class ChooserModalOnloadHandlerFactory {
     $('[data-multiple-choice-select]', containerElement).on('change', () => {
       this.updateMultipleChoiceSubmitEnabledState(modal);
     });
+
+    this.disabledDuplicateCheckboxes(modal);
   }
 
   updateMultipleChoiceSubmitEnabledState(modal) {
@@ -246,6 +248,28 @@ class ChooserModalOnloadHandlerFactory {
     }
   }
 
+  disabledDuplicateCheckboxes(modal) {
+    const openModalButton = modal.triggerElement;
+
+    if (openModalButton.hasAttribute('chooserids')) {
+      const selectedObjectIds = openModalButton
+        .getAttribute('chooserids')
+        .split(',')
+        .map(Number);
+
+      // eslint-disable-next-line func-names
+      $('[data-multiple-choice-select]', modal.body).each(function () {
+        const value = $(this).val();
+
+        if (selectedObjectIds.includes(parseInt(value, 10))) {
+          $(this).prop('disabled', true);
+        } else {
+          $(this).prop('disabled', false);
+        }
+      });
+    }
+  }
+
   modalHasTabs(modal) {
     return $('[data-tabs]', modal.body).length;
   }
diff --git a/wagtail/admin/panels/multiple_chooser_panel.py b/wagtail/admin/panels/multiple_chooser_panel.py
index 90b30aafa8..b9408ba9e4 100644
--- a/wagtail/admin/panels/multiple_chooser_panel.py
+++ b/wagtail/admin/panels/multiple_chooser_panel.py
@@ -6,18 +6,22 @@ from .inline_panel import InlinePanel
 
 
 class MultipleChooserPanel(InlinePanel):
-    def __init__(self, relation_name, chooser_field_name=None, **kwargs):
+    def __init__(
+        self, relation_name, chooser_field_name=None, allow_duplicates=True, **kwargs
+    ):
         if chooser_field_name is None:
             raise ImproperlyConfigured(
                 "MultipleChooserPanel must specify a chooser_field_name argument"
             )
 
         self.chooser_field_name = chooser_field_name
+        self.allow_duplicates = allow_duplicates
         super().__init__(relation_name, **kwargs)
 
     def clone_kwargs(self):
         kwargs = super().clone_kwargs()
         kwargs["chooser_field_name"] = self.chooser_field_name
+        kwargs["allow_duplicates"] = self.allow_duplicates
         return kwargs
 
     class BoundPanel(InlinePanel.BoundPanel):
@@ -38,6 +42,7 @@ class MultipleChooserPanel(InlinePanel):
         def get_context_data(self, parent_context=None):
             context = super().get_context_data(parent_context)
             context["chooser_field_name"] = self.panel.chooser_field_name
+            context["allow_duplicates"] = self.panel.allow_duplicates
             context[
                 "chooser_widget_definition"
             ] = self.chooser_widget_telepath_definition
diff --git a/wagtail/admin/templates/wagtailadmin/panels/multiple_chooser_panel.html b/wagtail/admin/templates/wagtailadmin/panels/multiple_chooser_panel.html
index 3cc6e945b8..b8126e11f2 100644
--- a/wagtail/admin/templates/wagtailadmin/panels/multiple_chooser_panel.html
+++ b/wagtail/admin/templates/wagtailadmin/panels/multiple_chooser_panel.html
@@ -20,6 +20,7 @@
                 canOrder: {% if can_order %}true{% else %}false{% endif %},
                 maxForms: {{ self.formset.max_num|unlocalize }},
                 chooserFieldName: "{{ chooser_field_name }}",
+                allowDuplicates: "{{ allow_duplicates }}" ,
             });
         })();
     </script>