diff --git a/.github/workflows/build_mpy_cross.yml b/.github/workflows/build_mpy_cross.yml
new file mode 100644
index 0000000000..2b7ba75e0f
--- /dev/null
+++ b/.github/workflows/build_mpy_cross.yml
@@ -0,0 +1,67 @@
+name: Build mpy-cross binaries
+
+on: workflow_dispatch
+
+jobs:
+  build:
+    runs-on: ubuntu-18.04
+    steps:
+    - uses: actions/checkout@v3
+    - name: Install packages
+      run: source tools/ci.sh && ci_mpy_cross_setup
+    - name: Build
+      run: source tools/ci.sh && ci_mpy_cross_build
+    - name: Archive binaries (Linux x64)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-linux-x64
+        path: mpy-cross/build-linux-x64/mpy-cross
+    - name: Archive binaries (Linux aarch64)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-linux-aarch64
+        path: mpy-cross/build-linux-aarch64/mpy-cross
+    - name: Archive binaries (Linux armhf)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-linux-armhf
+        path: mpy-cross/build-linux-armhf/mpy-cross
+    - name: Archive binaries (Windows x64)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-windows-x64
+        path: mpy-cross/build-windows-x64/mpy-cross.exe
+
+  build-i686:
+    runs-on: ubuntu-18.04
+    steps:
+    - uses: actions/checkout@v3
+    - name: Install packages
+      run: source tools/ci.sh && ci_mpy_cross_i686_setup
+    - name: Build
+      run: source tools/ci.sh && ci_mpy_cross_i686_build
+    - name: Archive binaries (Linux i686)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-linux-i686
+        path: mpy-cross/build-linux-i686/mpy-cross
+    - name: Archive binaries (Windows i686)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-windows-i686
+        path: mpy-cross/build-windows-i686/mpy-cross.exe
+
+  macos:
+    runs-on: macos-11.0
+    steps:
+    - uses: actions/checkout@v3
+    - uses: actions/setup-python@v4
+      with:
+        python-version: '3.8'
+    - name: Build
+      run: source tools/ci.sh && ci_mpy_cross_macos_build
+    - name: Archive binaries (macOS x64)
+      uses: actions/upload-artifact@v3
+      with:
+        name: mpy-cross-binaries-macos-x64
+        path: mpy-cross/build-macos-x64/mpy-cross
diff --git a/tools/ci.sh b/tools/ci.sh
index f94f23893b..14a61b2f89 100755
--- a/tools/ci.sh
+++ b/tools/ci.sh
@@ -711,3 +711,31 @@ function ci_zephyr_build {
     docker exec zephyr-ci west build -p auto -b mimxrt1050_evk
     docker exec zephyr-ci west build -p auto -b nucleo_wb55rg # for bluetooth
 }
+
+########################################################################################
+# mpy-cross
+
+function ci_mpy_cross_setup {
+    sudo apt-get install gcc-arm-linux-gnueabihf gcc-aarch64-linux-gnu gcc-mingw-w64
+}
+
+function ci_mpy_cross_build {
+    make ${MAKEOPTS} -C mpy-cross BUILD=build-linux-x64
+    make ${MAKEOPTS} -C mpy-cross BUILD=build-linux-aarch64 CROSS_COMPILE=aarch64-linux-gnu-
+    make ${MAKEOPTS} -C mpy-cross BUILD=build-linux-armhf CROSS_COMPILE=arm-linux-gnueabihf-
+    make ${MAKEOPTS} -C mpy-cross BUILD=build-windows-x64 CROSS_COMPILE=x86_64-w64-mingw32-
+}
+
+function ci_mpy_cross_i686_setup {
+    sudo apt-get install gcc-multilib gcc-mingw-w64-i686
+    # Note gcc-mingw-w64-i686 renamed to gcc-mingw-w64-i686-win32 in jammy
+}
+
+function ci_mpy_cross_i686_build {
+    make ${MAKEOPTS} -C mpy-cross MICROPY_FORCE_32BIT=1 BUILD=build-linux-i686
+    make ${MAKEOPTS} -C mpy-cross MICROPY_FORCE_32BIT=1 BUILD=build-windows-i686 CROSS_COMPILE=i686-w64-mingw32-
+}
+
+function ci_mpy_cross_macos_build {
+    make ${MAKEOPTS} -C mpy-cross BUILD=build-macos-x64
+}