diff --git a/extmod/moductypes.c b/extmod/moductypes.c
index 9b46371f36..d4c7611dfe 100644
--- a/extmod/moductypes.c
+++ b/extmod/moductypes.c
@@ -299,7 +299,7 @@ STATIC MP_DEFINE_CONST_FUN_OBJ_VAR_BETWEEN(uctypes_struct_sizeof_obj, 1, 2, ucty
 static inline mp_obj_t get_unaligned(uint val_type, byte *p, int big_endian) {
     char struct_type = big_endian ? '>' : '<';
     static const char type2char[16] = "BbHhIiQq------fd";
-    return mp_binary_get_val(struct_type, type2char[val_type], &p);
+    return mp_binary_get_val(struct_type, type2char[val_type], p, &p);
 }
 
 static inline void set_unaligned(uint val_type, byte *p, int big_endian, mp_obj_t val) {
diff --git a/py/binary.c b/py/binary.c
index a142776c37..9810e46600 100644
--- a/py/binary.c
+++ b/py/binary.c
@@ -185,14 +185,14 @@ long long mp_binary_get_int(mp_uint_t size, bool is_signed, bool big_endian, con
 }
 
 #define is_signed(typecode) (typecode > 'Z')
-mp_obj_t mp_binary_get_val(char struct_type, char val_type, byte **ptr) {
+mp_obj_t mp_binary_get_val(char struct_type, char val_type, byte *p_base, byte **ptr) {
     byte *p = *ptr;
     mp_uint_t align;
 
     size_t size = mp_binary_get_size(struct_type, val_type, &align);
     if (struct_type == '@') {
-        // Make pointer aligned
-        p = (byte*)MP_ALIGN(p, (size_t)align);
+        // Align p relative to p_base
+        p = p_base + (uintptr_t)MP_ALIGN(p - p_base, (size_t)align);
         #if MP_ENDIANNESS_LITTLE
         struct_type = '<';
         #else
diff --git a/py/binary.h b/py/binary.h
index 71182042f9..092b722886 100644
--- a/py/binary.h
+++ b/py/binary.h
@@ -38,7 +38,7 @@ size_t mp_binary_get_size(char struct_type, char val_type, mp_uint_t *palign);
 mp_obj_t mp_binary_get_val_array(char typecode, void *p, mp_uint_t index);
 void mp_binary_set_val_array(char typecode, void *p, mp_uint_t index, mp_obj_t val_in);
 void mp_binary_set_val_array_from_int(char typecode, void *p, mp_uint_t index, mp_int_t val);
-mp_obj_t mp_binary_get_val(char struct_type, char val_type, byte **ptr);
+mp_obj_t mp_binary_get_val(char struct_type, char val_type, byte *p_base, byte **ptr);
 void mp_binary_set_val(char struct_type, char val_type, mp_obj_t val_in, byte **ptr);
 long long mp_binary_get_int(mp_uint_t size, bool is_signed, bool big_endian, const byte *src);
 void mp_binary_set_int(mp_uint_t val_sz, bool big_endian, byte *dest, mp_uint_t val);
diff --git a/py/modstruct.c b/py/modstruct.c
index 8617a8e0d3..957e4917b6 100644
--- a/py/modstruct.c
+++ b/py/modstruct.c
@@ -146,6 +146,7 @@ STATIC mp_obj_t struct_unpack_from(size_t n_args, const mp_obj_t *args) {
         }
         p += offset;
     }
+    byte *p_base = p;
 
     // Check that the input buffer is big enough to unpack all the values
     if (p + total_sz > end_p) {
@@ -164,7 +165,7 @@ STATIC mp_obj_t struct_unpack_from(size_t n_args, const mp_obj_t *args) {
             res->items[i++] = item;
         } else {
             while (cnt--) {
-                item = mp_binary_get_val(fmt_type, *fmt, &p);
+                item = mp_binary_get_val(fmt_type, *fmt, p_base, &p);
                 res->items[i++] = item;
             }
         }
diff --git a/tests/basics/struct_endian.py b/tests/basics/struct_endian.py
new file mode 100644
index 0000000000..ae32438245
--- /dev/null
+++ b/tests/basics/struct_endian.py
@@ -0,0 +1,17 @@
+# test ustruct and endian specific things
+
+try:
+    import ustruct as struct
+except:
+    try:
+        import struct
+    except ImportError:
+        print("SKIP")
+        raise SystemExit
+
+# unpack/unpack_from with unaligned native type
+buf = b'0123456789'
+print(struct.unpack('h', memoryview(buf)[1:3]))
+print(struct.unpack_from('i', buf, 1))
+print(struct.unpack_from('@i', buf, 1))
+print(struct.unpack_from('@ii', buf, 1))